Big homogenizes culture, and destroys local community and culture. Think globalization and global trade pacts.
Big, as a top down operation accumulates corruption and influence buying like predator fish accumulate mercury.
Big cuts jobs
Big and its centralization produces disconnection from nature and humanity-- intentional disconnection-- Big media, big education
Big is bullying
Big is treated as though it is immortal
Big avoids accountability and regulation
Bigness is more masculine.
God is big
There are more. Please them in the comments
Bigness has evolved as a central dimension of civilization. But I challenge whether it is a necessary or even optimal element. Perhaps, the next step after big is small, a fractal pulse that raises freedom, democracy, connection and humanity to the next level.
I've written, in my article, Treating Extreme Wealth As a Disease, about how wealth and the desire for money can be psychologically pathological related to addiction, narcissism, depression or psychopathy. It may be that the need and desire for bigness is sometimes a pathologically neurotic or psychotic behavior.
We see some consumer manifestations of bigness-need that have unnecessary risks.
-consumerism-- always needing more and bigger